MY STUDY

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After years of alleatory reading, trying to understand the mechanism of stress, this is what I got by now.

I thought for years that cortisol disregulations (too high or too low) must be due to a malfuncioning of the adrenal glands. I walked on this pathway for very long, thinking that the disregulations of my blood glucose, of triglycerides and of cortisol must be due to the adernal malfunction, more specifically what some name ADRENAL FATIGUE.

Only lately I wanked up on the HPA axis, in order to realize that a disregulation in the production of the CRH hormone from the brain hypothalamus can disregulate the HPA axis, the cortizol production and gives a chain of reactions in the body, from immunocompetence to glucose disregulations.

Cadidiasis patients may have a deffect in the CRH gene, which I am not sure that can be fixed. If aquired, possibly it can be fixed.

Sleep deprivation and stress both increase CRH levels. HPA axis, according to some medical sciencemen, may become irresponsive to CRH after some time when CRH is continuously at abnormally high levels. For now Iam not sure about the truth of this assertion.

CRH ust therefore be controlled either by decreasing CRH prodution itself or by targeting the CRH receptors, which is harder to achieve.

Benzodiazepines have the property of attenuating the pituitary-adrenal responses to corticotrophin-releasing hormone in healthy subjects, but not in those with Cushing's Syndrome.

Alprazolam attenuates vasopressin-stimulated adrenocorticotropin and cortisol release: evidence for synergy between vasopressin and corticotropin-releasing hormone in humans.

Alprazolam (APZ), a triazolobenzodiazepine with unique clinical utility, has potent inhibitory effects on the human hypothalamic- pituitary-adrenal axis. Because APZ inhibits CRH secretion from isolated rat hypothalami and inhibits the probable CRH-mediated effect of naloxone on ACTH release, it is likely APZ acts as an inhibitor of hypothalamic CRH release in humans.

Chronic elevated CRH might blunt the CRH receptors and these might become irresponsive. Adjusting CRH levels might eventually be a way of conserving the CRH receptors and hopefully to restore their previous ability to work properly.

This might be achieved with CHR inhibitors aka benzodiazepines.