Possible Mechanism By Which Collagen Intake Can Cause Weight Gain

 

IN BRIEF:

Exogenous collagen leads to --> High levels of collagen in the bloodstream --> Triggers the production of Ghrelin in an attempt to remake the balance --> Ghrelin induces hunger and leads to weight gain.

 

DETAILED: 

Unusually high levels of collagen in the bloodstream will trigger the production of ghrelin hormone, in an attempt to suppress the endogenous collagen production. Ghrelin is called the "hunger hormone" and increases appetite. 

 

Collagen and Ghrelin are both peptides, so perhaps they have some affinity for each other, or use similar mechanisms. 

High collagen deposition impedes the heart and the kidneys to perform their functions, so high collagen in the bloodstream will be fought by various mechanisms, one of them being Ghrelin production.
 

When the body is flooded with exogenous collagen, Ghrelin production increases, in order to help with diminishing the endogenous production of collagen, in a try to rebalance. 

Ghrelin  also decreases thyroid hormone and testosterone. 

Low levels of thyroid hormone and testosterone are well-known for triggering weight gain. 

QUOTES: 

Ghrelin is a hormone that sends a signal to your brain to feel hungry. 

https://www.healthline.com/nutrition/ghrelin#:~:text=These%20days%2C%20if%20you%20under,intake%20and%20body%20fat%20levels.

Ghrelin is termed the 'hunger hormone' because it stimulates appetite, increases food intake and promotes fat storage.

https://www.yourhormones.info/hormones/ghrelin/#:~:text=Ghrelin%20is%20a%20hormone%20that,intake%20and%20promotes%20fat%20storage.

Ghrelin attenuates collagen production in lesional fibroblasts from patients with systemic sclerosis

https://pubmed.ncbi.nlm.nih.gov/23571102/

Ghrelin levels increase during a diet and intensify hunger, making it hard to lose weight
Ghrelin protects the heart against cardiac dysfunction by inhibiting excessive collagen deposition
Ghrelin inhibits renal fibrosis by attenuating the production of collagen
Ghrelin decreases thyroid hormone and testosterone

https://www.hindawi.com/journals/ije/2020/1385138/

Ghrelin - peptide link: Ghrelin is a gastric peptide hormone

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863518/

Collagen - peptide link: The beginning of collagen synthesis begins with turning on genes which are associated with the formation of a particular alpha peptide

https://en.wikipedia.org/wiki/Collagen

 

Mechanisms of cardiac collagen deposition in experimental models and human disease

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996650/

 

The roles of collagen in chronic kidney disease and vascular calcification

https://link.springer.com/article/10.1007/s00109-020-02014-6

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Mask Hypoxia - Ischemic Stroke Possible Link

Mask Hypoxia in Subjects Using Masks to Prevent Infection Spread
https://clinicaltrials.gov/ct2/show/NCT04670484

Hypoxia (oxygen deprivation) is known to be associated with deep vein thrombosis and venous thromboembolism.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627841/

 
New link between hypoxia and blood clot risk
https://www.sciencedaily.com/releases/2018/08/180802115657.htm#:~:text=Summary%3A,threatening%20blood%20clots%20(thrombosis).

 
Ischemic stroke occurs when a blood clot blocks or narrows an artery leading to the brain.
https://www.mayoclinic.org/ischemic-stroke/img-20009031

 
Study shows a possible connection between stroke-like symptoms and coronavirus
by Talia KirklandFriday, May 8th 2020
https://local21news.com/news/local/studies-show-a-possible-connection-between-stroke-like-symptoms-and-coronavirus

 
Hypoxic-ischemic encephalopathy, or HIE, is the brain injury caused by oxygen deprivation to the brain, also commonly known as intrapartum asphyxia. 

https://www.cerebralpalsy.org/about-cerebral-palsy/cause/hypoxic-ischemic-encephalopathy

Acute hypoxemia may result in hypoxic ischemic encephalopathy.
Prolonged hypoxia also causes BBB disruption leading to leaky capillaries which can produce microhemorrhages.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284232/

 
Acute hypoxemia (see also Oxygen Desaturation) may cause dyspnea, restlessness, and anxiety. Signs include confusion or alteration of consciousness, cyanosis, tachypnea, tachycardia, and diaphoresis. Cardiac arrhythmia and coma can result.
https://www.msdmanuals.com/professional/critical-care-medicine/respiratory-failure-and-mechanical-ventilation/acute-hypoxemic-respiratory-failure-ahrf,-ards?redirectid=8#:~:text=Acute%20hypoxemia%20(see%20also%20Oxygen,arrhythmia%20and%20coma%20can%20result.
 

DECEASED COVID-19 PATIENTS SHOW HYPOXIC INJURY IN THE BRAIN
“Our findings showed high levels of hypoxic-ischemic injury, which is to be expected in patients with severe lung disease,” says Isaac Solomon, MD, PhD, a pathologist in the Brigham’s Department of Pathology.
Autopsies Show Hypoxia, Not Encephalitis
When the brain is deprived of oxygen for an extended period of time, neurons begin to die, which tends to be most evident in the hippocampus, cerebellum and cerebral cortex. Pathologists observed neuronal death in these brain areas of all 18 patients. But there wasn’t any evidence of encephalitis, or acute inflammation in the brain, which is typically seen in arboviruses, human immunodeficiency virus (HIV), and herpes simplex virus (HSV-1).
“We didn’t see any histological evidence of the virus,” says Dr. Solomon. “With viral encephalitis, we typically see a plethora of lymphocytes and microglia, which destroy virus-infected neurons, but we didn’t see anything like that.”
https://www.brighamhealthonamission.org/2020/07/29/deceased-covid-19-patients-show-hypoxic-injury-in-the-brain/

 
Preliminary report on surgical mask induced deoxygenation during major surgery
https://scielo.isciii.es/pdf/neuro/v19n2/3.pdf

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